Pathophysiology Of Diabetes 3i4o5i
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Diagrams: Diagram I Pathogenesis of Insulin Dependent DM (Type 1) Genetic Predisposition (Susceptibility)
Environmental insult
Autoimmunity -Lymphocyte infiltration -Insulitis
- Viral infection - Toxic chemical agents
Immunologic Response -
Islet cell antibodies Cell- mediated immunity
β cell destruction
Lack of insulin release
Insulin Dependent Diabetes Mellitus (IDDM)
Diagram II Pathogenesis of Non- Insulin Dependent DM (Type 2) Hereditary Factors
Obesity
Delayed or insufficient insulin secretion
Insulin resistance (Receptor defect or other events)
Increased insulin demand
Β cell exhaustion and dysfunction
Impaired secretion of insulin
Hyperglycemia
Non- Insulin Dependent DM (NIDDM)
Environmental insult
Autoimmunity -Lymphocyte infiltration -Insulitis
- Viral infection - Toxic chemical agents
Immunologic Response -
Islet cell antibodies Cell- mediated immunity
β cell destruction
Lack of insulin release
Insulin Dependent Diabetes Mellitus (IDDM)
Diagram II Pathogenesis of Non- Insulin Dependent DM (Type 2) Hereditary Factors
Obesity
Delayed or insufficient insulin secretion
Insulin resistance (Receptor defect or other events)
Increased insulin demand
Β cell exhaustion and dysfunction
Impaired secretion of insulin
Hyperglycemia
Non- Insulin Dependent DM (NIDDM)
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