Isoket f5r7

Name of Drug Generic Name: Isosorbide dinitrate Brand Name: Isoket Classification: Antianginal Dosage: Injection: 0.5 mg/ml Route: I.V

Mechanism of Actions

Indication

It relaxes vascular Dinitrate: Treatment smooth muscle with and prevention of a resultant decrease angina pectoris in venous return and decrease in arterial BP, which reduces left ventricular workload and decreases myocardial oxygen consumption.

Contraindication

Side Effect

Contraindicated with allergy to nitrates, severe anemia, head trauma, cerebral hemorrhage, hypertrophic cardiomyopathy, narrow-angle glaucoma, postdural hypotension

Frequent: Headache, Dizziness, Weakness, Nausea, Flushing, a drop in blood pressure that occurs when moving from a lying down or sitting position to sitting or standing, which results in dizziness and lightheadedness (postural hypotension), Increased heart rate (tachycardia), Decreased heart rate (bradycardia), Allergic skin reactions, Fainting.

Use cautiously with pregnancy, lactation, acute MI, CHF.

Nursing responsibilities Assessment: >History: Allergy to nitrates, severe anemia, GI hypermobility, head trauma, cerebral hemorrhage, hypertrophic cardiomyopathy, pregnancy, lactation Physical: Skin color, T, lesions; orientation, reflexes, affect; P, BP, orthostatic BP, baseline ECG, peripheral perfusion; R, adventitious sounds; liver evaluation, normal output; CBC, Hgb > Give sublingual preparations under the tongue or in the buccal pouch;

discourage the patient from swallowing. >Create a nitrate-free period to minimize tolerance. > Keep life equipment readily available if overdose occurs or cardiac condition worsens. > Gradually reduce dose if anginal treatment is being terminated; rapid discontinuation can lead to problems of withdrawal.