Describe the differences between the original and mutated sequences. The original sequence is changed when mutated by C nucleotides and Pher amino acids. How many amino acids were changed? There were four amino acids changed. Was the sequence a result of point or frameshift mutation? The sequence was a result of frameshift mutation. Explain why all mutations are not necessarily harmful. Mutations usually have little or no impact on the organism due to several complex systems that fix damaged DNA. Does changing the sequence of nucleotides always result in a different amino acid sequence? Explain. Almost always but different sequences of nucleotides can sometimes result in the same or correct amino acid being transcribed.